Topiramate in Treatment of Tourette Syndrome

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A randomised, double-blind, placebo-controlled study of topiramate in the treatment of Tourette syndrome.

OBJECTIVE To investigate the effects of topiramate on Tourette syndrome (TS). BACKGROUND Dopamine-receptor-blocking drugs have been traditionally used to control tics in patients with TS, but these neuroleptics are associated with potentially limiting side effects. METHODS This is a randomised, double-blind, placebo-controlled, parallel group study. To be included in the study, subjects req...

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Treatment strategies for tics in Tourette syndrome.

TOURETTE SYNDROME (TS) IS A CHRONIC NEURODEVELOPMENTAL DISORDER CHARACTERIZED BY TICS: repetitive, involuntary movements and vocalizations. These symptoms can have a significant impact on patients' daily functioning across many domains. Tics tend to be most severe in child and adolescent sufferers, so their presence has the potential to impact a period of life that is both critical for learning...

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Treatment of Tourette Syndrome with Cannabinoids

Cannabinoids have been used for hundred of years for medical purposes. To day, the cannabinoid delta-9-tetrahydrocannabinol (THC) and the cannabis extract nabiximols are approved for the treatment of nausea, anorexia and spasticity, respectively. In Tourette syndrome (TS) several anecdotal reports provided evidence that marijuana might be effective not only in the suppression of tics, but also ...

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Nifedipine augments haloperidol in the treatment of Tourette syndrome.

In anecdotal case reports, verapamil and nifedipine, calcium channel blockers, have provided rapid and dramatic relief in refractory Tourette syndrome [ 1,2]. The following report illustrates the use of nifedipine to augment haloperidol in the treatment of a child who did not respond when either drug was used alone. This 9-year-old boy was referred for intractable Tourette syndrome over a 3 yea...

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ژورنال

عنوان ژورنال: Clinical Neuropharmacology

سال: 2010

ISSN: 0362-5664

DOI: 10.1097/wnf.0b013e3181c295c1